Applied Biocatalysis by John Whittall

Author:John Whittall [Whittall, John]
Language: eng
Format: epub
ISBN: 9781119487036
Published: 2020-08-15T09:01:27+00:00

Scheme 8.2 General synthesis route to δ‐lactones 8 via: 2‐deoxyribose‐5‐phosphate aldolase (DERA) reaction of an aliphatic aldehyde 1 with two equivalents of acetaldehyde 2 (via mono‐aldol intermediate 3 and sponateous ring‐closure of hydroxy‐aldehyde 4); oxidation of the lactol intermediate 5 to a hydroxy‐lactone 6; water elimination to α,β‐unsaturated lactone 7; and double bond reduction to δ‐lactone 8.

Scheme 8.3 Oxygen and NADP+ oxidation of lactol 9 derived from DERA reaction with pentanal and acetaldehyde to the corresponding hydroxy‐lactone 10 using commercial ADH‐99 (c‐LEcta) and water, forming NOX‐01 (InnoSyn) for NADPH regeneration to NADP+.

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